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JAMA 311, 18891900

doi: 10.1080/09553000802241762 10 CarnesBAGrdinaDJ

Read preprocessing: Paired-end reads were interleaved using seqtk merge ( Adapter sequences and low-quality bases were trimmed using fastp ( with default parameters

Heme-mediated reactive oxygen species toxicity to retinal pigment epithelial cells is reduced by hemopexin

Both inducers lead to rapid induction of MT mRNA, but while the response to metal is biphasic and the level of the mRNA declines after prolonged exposure, the response to the hormone is persistent and once a new elevated steady state level of MT mRNA is achieved, it is maintained as long as the hormone is present heavy metal induction is mediated through the removal of a repressor of MT gene expression

Brain 143 , 15881602 (2020)