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Reduction in estrogen levels throughout aging and menopausal periods is suggested to be associated with increased oxidative stress and mitochondrial dysfunction, exacerbated proinflammatory responses, and reduced synaptic plasticity (249, 254, 255)

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283 , C178C186 (2002)

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This interaction was also observed in OCT1 29 , and we note R282 is a part of a PESPR motif conserved in OCTs and OATs and found in glucose transporters 54