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261 In addition, an aggregation-induced emission luminogen (AIEgen) based photosensitizer (TPE-PyT-CPS) can also effectively target the Golgi apparatus via caveolin/raft mediation endocytosis, and Golgi apparatus protein (p115/GM130) exhibits Golgi apparatus fragmentation and cleavage under light irradiation, and further activate the apoptotic pathway, resulting in Golgi apparatus targeting TPE-T-CPS showing better anti-tumor effects in tumor-bearing mice compared to the non-Golgi apparatus-targeting TPE-PyT-PS

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In the major obesity and diabetes trials, Tirzepatide was typically studied at 5 mg, 10 mg and 15 mg maintenance doses , with escalation from a lower starting dose over a period of weeks to improve tolerability

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