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Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

doi: 10.1007/s12035-014-9070-5 177 HunotSBoissireFFaucheuxBBruggBMouatt-PrigentAAgidYet al

169 In addition, the aging process is linked with a decrease in CD4, and CD8 T cell populations

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