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The peptide's actin-sequestering activity enables the rapid cytoskeletal reorganization required for keratinocyte migration and fibroblast movement into wound sites, with studies showing 2-3 fold increases in migration rates and improved directional persistence compared to untreated controls

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We then examine several compounds capable of promoting NRF2 activity thereby inducing cytoprotective effects, and which are currently in different stages of clinical development for many pathologies, including neurodegenerative diseases