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For the flower dataset, n = 3 independent flowers were profiled ( n = 2 in transverse orientation, n = 1 in longitudinal orientation) across two experiments

10.3389/fphar.2021.817236 20 BonnetA.MoreauP

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It is aggressive, can invade surrounding tissue, and often metastasizes, particularly to the lungs

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Overall, our findings establish Drosophila as a powerful genetic model for studying endogenous D-2HG metabolism and suggest that future studies of the D2hgdh mutants will advance our understanding of how loss of D2hgdh activity results in disease phenotypes