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Subsequently, bacteria and LPS are translocated into the liver through the portal vein, activating the TLR4/NF-B signaling pathway of liver Kupffer cells, and promoting the production of inflammatory cytokines such as TNF-, IL-6 and IL-1 (Jiang and Schnabl, 2020)

doi: 10.3390/cosmetics2020110 [DOI] [Google Scholar] 97.Mahendiratta S, Sarma P, Kaur H, et al

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During adaptive immunity, Lactobacillus, Clostridium, Bifidobacterium , and Enterococcus in the gut can reduce inflammatory responses by producing lipid metabolites and reducing tumor necrosis factor (TNF-), and inflammatory mediators interleukin-1(IL-1), interleukin-6 (IL-6), and interleukin-18(IL-18) (175178)

It has also been reported that cholesteryl ester transfer protein (CETP) can transport cholesterol from high-density lipoprotein to lipoprotein containing apolipoprotein B (ApoB) and rich in TG, such as chylomicron remains (containing ApoB-48) and VLDL remains (containing ApoB-100)