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In the presymptomatic period, higher GFAP plasma concentrations correlated with a lower cognitive score and lower brain volumes, suggesting that GFAP expression is increased in the late presymptomatic period 227

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2023;112(104546) doi: 10.1016/j.cryobiol.2023.05.003

To activate efficient T cell immunity, a moderate level of ROS is needed, however, excessive ROS would cause toxicity to the T cells, because the improper level leads to the formation and maintenance of an immunosuppressive tumor microenvironment