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A sufficiently large mass had to be melted, for instance by using a longer laser pulse

Furthermore, sourcing introduces uncertainty in sterility and formulation integrity, which may represent a more immediate and clinically relevant risk than theoretical biologic effects, particularly given the potential for nonsterile preparation, contamination, or inconsistent formulation in nonregulated injectable products

doi: 10.1016/0304-3940(96)12552-0

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