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Low cortisol levels may suggest poor adrenal function or Addisons disease

Here we establish a human primary culture system that allows sensitive discrimination of cell fate dynamics and apply single-cell CRISPR interference (CRISPRi) screening 13,14 to examine the transcriptional and cell fate consequences of 44 TFs active during cortical neurogenesis

doi: 10.1152/physrev.00018.2001

This study has some limitations
Mercer J, Helenius A
