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18.50 5.48 in LC group and 17.37 4.71 in the control group for the APACHE II ( p- value : 0.394)

In another study, EGCG was observed to suppress the expression of TNF, IL-1, IL-6, and inducible nitric oxide synthase (iNOS), restoring the levels of intracellular antioxidants against free radical-induced pro-inflammatory effects in microglia, nuclear erythroid-2 related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) [143]

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doi: 10.1007/s40265-019-01114-z 325 RayKKWrightRSKallendDKoenigWLeiterLARaalFJet al

36,46 FAs are -oxidized in mitochondria or esterified to be excreted as very low-density lipoprotein or stored as lipid droplets

Especially in UPR, although TMAO can selectively activate PERK-mediated UPR by binding to PERK, this does not explain TMAO-mediated aggregation of unfold or misfolded proteins in AD