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WHO (2022)

8(9): p

The impact of impaired synaptic plasticity extends beyond the cellular level and manifests in behavioral outcomes

Li X, Li C, Zhang W, Wang Y, Qian P, Huang H

Although uterine expression levels of estrogen receptor , G protein-coupled estrogen receptor, and steroid synthase were upregulated in the high-dose group, the decreased expression of connexin 43 and alkaline phosphatase as well as the increased expression of insulin-like growth factor-binding protein three and monoamine oxidase were consistent with decreased estrogen signaling and lower uterine weights

In several meta-analyses, UPT was found to be the most effective small molecule drug for inducing clinical remission and clinical response, but it had the highest incidence of adverse events in patients with moderate to severe UC [12, 179]