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Unfortunately, NAD+ levels decline with age, stress, poor diet, and metabolic dysfunction

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The only positive news I have seen is that it gets better over time as in reduces over time

This is a stark contrast to the typically slow improvement of polyneuropathy in POEMS, and could imply that at least part of the underlying mechanism causing neuropathy in POEMS may be related to vitamin B6 deficiency, and that an evaluation of vitamin levels in POEMS may be currently underappreciated

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