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For example, metabolic inhibitors such as metformin and doxycycline, which target OXPHOS and mitochondrial biogenesis, respectively, have demonstrated variable efficacy against CSCs

V.CrossonJ.T.etal.1985 Fechtner syndrome: a variant of Alports syndrome with leukocyte inclusions and macrothrombocytopenia,65397406

Therefore, this indicator may also be associated with disease severity, as evidenced by different levels of DJ-1 in blood from PD patients at different stages and healthy controls (Lin et al., 2012)

Lee JY, Lee YH

Spectrochim Acta A Mol Biomol Spectrosc 135:551559