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77 : 13701376 Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR and Haynes WG (1999) Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans

23 , 24 The synovial space is another site that is greatly affected by ROS in the onset of OA

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Keywords: oxidative damage, oxidative stress, reactive oxygen species, redox signaling, therapeutic targets Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases

All land routes were restricted to the seasons where travel was feasible

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