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Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis

25 , 10911102.e1094 (2017)

ROS are free radicals, or unstable molecules, that contain oxygen and easily react with other molecules in a cell

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In rat models of complete Achilles tendon transection, BPC-157 administration significantly accelerated healing with improved functional outcomes, biomechanical strength, and histological organization compared to untreated controls

In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients
