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2 Activated JAK induces the phosphorylation of STAT3, which translocates to the nucleus, where it promotes the expression of cell proliferation-related genes

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ClinicalTrials.gov Identifier: NCT01050621

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This was related to a decreased expression of Ki67 (a marker of cell proliferation) and a downregulation of cyclin A, cyclin D1, and CDK2, which regulate cell cycle progression (31)

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