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90 2D images were acquired using transmission electron microscope (FEI Tecnai Sprit 120 kV)

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For progression-free interval 38 p -value minimization 37,94 , R-packages survival 95 and survminer 96 were used

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Biochemical assays of tissues Lipids of tissue, serum exosome, cell lysate, and supernatant were extracted by the Folch method 77

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