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Under high-phosphate conditions, N- and O-glycosylation of cytochrome p450 27B1 (CYP27B1) enhances RUNX2 expression, while O-Linked N-acetylglucosamine transferase (OGT)-mediated YAP glycosylation inhibits autophagy, accelerating disease progression under hyperphosphatemia with CKD (Yimamu et al., 2022

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