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Primarily, women in adolescence or middle age develop vocal fold nodules

The innate immune system not only serves as the first line of defense but also shapes adaptive immune responses through cytokine and chemokine secretion, co-stimulatory signals, and direct immune cell interactions ( Figure 3 )

Behav Brain Funct 14:14 Djiogue S, Halabalaki M, Njamen D, Kretzschmar G, Lambrinidis G, Hoepping J, Raffaelli FM, Mikros E, Skaltsounis AL, Vollmer G (2014) Erythroidine alkaloids: a novel class of phytoestrogens

Furocoumarin derivatives increased the number of skin basal layer melanocytes and melanin-containing hair follicles, and upregulated melanin synthesis and TYR activity by activating cAMP/PKA and MAPK signalling pathways [268]