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Whether GSH-dependent copper trafficking and Fe-S cluster maintenance actively license ferroptosis or cuproptosis, rather than simply buffering stress, remains unclear
In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)
Mechanistic insights into allosteric regulation of the A 2A adenosine G protein-coupled receptor by physiological cations
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Many Gram-negative bacteria, such as E
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