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The Arg3 substitution and N-terminal 13-residue extension in IGF-1 LR3 reduce IGFBP affinity by approximately 1,000-fold, preventing this sequestration

Astrocytes control extracellular K + primarily through the astrocyte-specific 2-subunit containing Na + K + pump and astrocytic inward rectifying K ir 4.1 K + channels 71

In those with diabetic peripheral neuropathy, gabapentin and duloxetine were equally effective, however, gabapentin showed an earlier effect but more side effects while duloxetine had better medication compliance [93]

MPTP treatment led to a marked reduction in GSH levels, while GCLC overexpression effectively restored GSH concentrations in both serum and brain tissues (Fig