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These approaches encompass systemic administration of lactate-enriched solutions to provide metabolic support, as well as interventions aimed at inhibiting lactate production or transport as well as promoting its depletion to disrupt metabolic symbiosis in tumors, highlighting the dual therapeutic potential of lactate (150,151)

Final report on the safety assessment of niacinamide and niacin

Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape

Carnitine metabolism and deficit: when supplementation is necessary

Using metabolite kinetics with the assumption that Cys is a metabolite of GSH, Cys concentration over 20 M would be achieved when GSH were administered at 50 mg/kg body weights every 205.4 min

doi: 10.1016/j.tree.2018.12.002 136