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elegans by ERGO (Fig

The substantia nigra is the brain region with the lowest concentration of ascorbate (Grmewald, 1993), which could be considered a susceptibility factor for oxidative stress if we consider that the synthesis of dopamine is pro-oxidant and needs ascorbate

Cancer 104 , 788793 (2005)

This might be caused by the multiple and complementary beneficial effects of vitamin C on different pathology phases, which are currently underestimated or even ignored in clinical applications

Benefits were more pronounced in studies using 6001,200mg per day over at least eight weeks.2 A 2022 randomized controlled trial in patients with metabolic syndrome found that 600mg of ALA daily for 12 weeks significantly reduced triglyceride levels and total cholesterol compared to placebo.59 However, the study did not observe significant changes in LDL-C or HDL-C

In a diet-induced obese mouse model, amkinone at 10 mg/kg/day dose showed improvement in glucose tolerance and insulin sensitivity concomitant with the reduction in adiposity and body weight without affecting food consumption