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These agents directly stimulate salivary flow by agonizing the M3 muscarinic receptors located on salivary acinar cells

However, broad interstudy and regional variations can be observed and it seems that the decrease in microbial diversity is a more relevant factor in AD-related dysbiosis

[DOI] [PMC free article] [PubMed] [Google Scholar] Liu A, Frostegrd J

(2012) Mutation of Glu 521 or Glu 535 in cytoplasmic loop 5 cause differential misfolding in multiple domains of the multidrug and organic anion transporter MRP1 ( ABCC1 )

The function of ERK1/2 leads to an increase in cellular mitogenic messages, which is indirectly triggered by PKA through the increased intracellular calcium induced by PLC/PKC events, both of which, according to the description, have been stimulated by IGF activity [53, 65]

doi: 10.1016/j.rasd.2019.101473