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We therefore conducted an updated systematic review and NMA of European Medicines Agency (EMA) approved obesity management medications (OMMs) available in Europe, incorporating evidence published up to 21 November 2025 to reassess their comparative efficacy and safety for body weight reduction and obesity-related complications in adults

Statistical analyses were conducted using t-tests or Mann-Whitney U tests, and Pearson or Spearman correlations, depending on data distribution

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How Semaglutide Resistance Develops in the Body Semaglutide activates GLP-1 receptors in your brain and gut to reduce hunger and slow digestion