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[PMC free article] [PubMed] [Google Scholar] Wood 2008 Wood L, Egger M, Gluud LL, Schulz KF, Juni P, Altman DG, et al

They are naturally occurring, biologically active, coenzyme forms of vitamin B12

Gutirrez E, Flammer AJ, Lerman LO, Elzaga J, Lerman A, Fernndez-Avils F

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Further structural optimization delivered a large number of macrocyclic disulfides and among them 23 (HA08) encompassing a 3-homotyrosine residue in a 13-membered ring system and exhibiting the lowest Ki value in the series (Ki = 3.3 nM)

It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the ageing process