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The common disadvantage of these studies is that they only include a small number of cases

Similarly, Cheung et al [56] demonstrated that miR-125b-5p expression is upregulated by glucose in an AMP-activated protein kinase (AMPK)-dependent manner and targets the transporter of lysosomal hydrolases, cation-dependent mannose-6-phosphate receptor (M6PR), and the mitochondrial fission regulator, mitochondrial fission process protein 1 (MTFP1), to regulate organelle dynamics and impair glucose-stimulated insulin secretion

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The prediction of colonic absorption in vitro can be challenging, and we have found that the judicious use of an animal model can help to tease out absorption-related issues, as is the case for most modified-release drug delivery development

doi: 10.1126/sciadv.abg3188