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On occasion, amoxicillin-clavulanate, like other cholestatic hepatotoxic drugs, causes permanent injury to small bile ducts, leading to the so-called vanishing bile duct syndrome. In vanishing bile duct syndrome, initially, liver injury is minimal except for severe cholestasis

These observations suggest that local accumulation of mercury in the lung is a key mechanism contributing to its cytotoxicity, primarily through the induction of oxidative stress and inflammation

PLoS ONE 11 , e0158369 (2016)

10.1016/S0014-5793(99)00147-7 3 AllocatiN.CasaloneE.MasulliM.PolekhinaG.RossjohnJ.ParkerM