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By the 1890s, the competition had become explicit, with city leaders eyeing with envy and suspicion developments in each others community

Vitamin B12 is known as cobalamin

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In some embodiments, otic administration of the formulations or compositions described herein avoids toxicity associated with systemic administration (e.g., hepatotoxicity, cardiotoxicity, gastrointestinal side effects, and renal toxicity) of the active agents

With the advancement of in silico tools to identify T cell epitopes, this trial and error mutagenic approach spanning the entire sequence of the protein therapeutic can be avoided

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