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Shrauner W, Lord EM, Nguyen XT et al (2022) Frailty and cardiovascular mortality in more than 3 million US Veterans
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The more recent STEP UP trial tested a higher dose of 7.2 mg and showed average weight loss of 20.7% at 72 weeks

You rarely slow down and when you do, its not for long
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Better sleep quality can lead to increased energy levels and improved mood
