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All human genes associated with these categories were obtained by propagating gene membership in the GO hierarchical tree using the GO.db (v.3.14), AnnotationDbi (v.1.56.2) and org.Hs.eg.db (v.3.14.0) packages in R (date of access: 7 April 2022)

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This indicates that the intestinal microbiota metabolite IDA can enhance FSP1-mediated synthesis of reduced coenzyme Q10 via the AhR-ALDH1A3 pathway, leading to NADPH production, ferroptosis inhibition, and ultimately promoting the progression of colorectal cancer (91)