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PMCID: PMC7416373

The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: formation of a disulfide-linked protein complex

Chelation therapy may pose risks for individuals with unstable heart conditions, as it can affect blood pressure and electrolyte balance

Cytoplasmic IDH1 and mitochondrial isocitrate dehydrogenase 2 (IDH2) reversibly synthesize -ketoglutarate from isocitrate and function in the reversible mitochondrial citrate--ketoglutarate shuttle (CAS) that shuttles NADPH reducing equivalents between the cytoplasm and the mitochondrial matrix (Figure 2D)

Elevated ammonia levels are highly neurotoxic

transition to 12 injections per week for maintenance dosing to sustain pigmentation [3]
