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Adverse reactions may also occur in the event of significant drug interactions

Long term biweekly 1 mg oral vitamin B12 ensures normal hematological parameters, but does not correct all other markers of vitamin B12 deficiency

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Homocysteine itself antagonizes NMDA receptors and can induce excitotoxic neuronal death at high concentrations, which might contribute to the neuropathological features observed in ASD (such as altered synaptic pruning)

The H3 receptors are acting as a feedback loop to restrict histamine and other neurotransmitter release in certain brain regions.[ref] The study also linked histaminergic neuron expression and changes in the brain to ADHD and major depressive disorder