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The mice were pretreated with dopamine antagonist haloperidol (5.0 mg/kg i.p.) and subsequently treated with amphetamine (20 mg/kg i.p.1, 2, 4 and 10 days after haloperidol pre-treatment), which is usually used for the study of behavioral supersensitivity to an amphetamine stimulating effect

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Regarding the neuroinflammation, VD induces the transcription of thioredoxin superfamily member 4 (THEM4) and subsequently inhibits Akt phosphorylation and the NF-B pathway, ultimately resulting in the down-regulation of IL-1, IL-2, IL-6, IL-8, TNF- and COX expression

The production of NO from arginine is catalyzed by the enzyme nitric oxide synthase (NOS) via the L-arginine-NO pathway [86]

Suntres, Z

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