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Insulin/IGF-1/FoxO signaling and acne Acne is epidemic in adolescents of Western life style and absent in populations consuming a Paleolithic diet excluding sugar, grains and dairy like the Kitava islanders who exhibit low basal insulin levels compared with age-matched Europeans [15]

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[PUBMED Abstract] Sun W, Malvar J, Sposto R, et al.: Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

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This RCT is consistent with the recommended framework for proof-of-concept trials which target fundamental processes of aging (24)

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