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EPA determined that evidence is not sufficient to support a MOA of cytotoxicity followed by sustained cell proliferation as a required precursor to tumor formation related to the metabolic saturation and accumulation of the parent compound, 1,4-dioxane (Dourson et al., 2017

10.1016/j.oraloncology.2019.02.001 75 ZhangJ.YuM.ZhangT.SongX.YingS.ShenZ.et al (2024)

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Here's to lighter Eyes

A detailed introduction of the structure and function of BBB was given based on the mechanism of BBB, while comparing with the pathological changes of BBB in neurodegenerative diseases (NDDs), including activation of endothelial cells, the loose of tight junction and increase of BBB permeability

Serotonin Neuron Development: Shaping Molecular and Structural Identities