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Science 124: 269270 Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB (2010) The hexosamine biosynthetic pathway couples growth factorinduced glutamine uptake to glucose metabolism

Zhu B, Dong Y, Xu Z, Gompf HS, Ward SA, Xue Z, et al

Front Cardiovasc Med 2022

In non-pathologic conditions, the cortex activates the indirect pathway with a smaller contribution of inhibition through SNpc dopamine release on D2-receptor cells in the striatum

doi: 10.1007/S11356-020-09617-Z 198

Future efforts should focus on translating these mechanistic advances into clinically validated tools through multi-omics-based risk stratification and personalized therapeutic strategies, with the ultimate goal of reducing the persistently high mortality associated with intestinal I/R injury