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Description
Fumarylacetoacetate and fumarylacetone are also chemically reactive alpha-beta unsaturated ketones, however, fumarylacetoacetate and fumarylacetone (but not their cis isomers) are substrates for fumarylacetoacetate hydrolase (FAH)

- This binding activates the insulin receptor and triggers an internal cascade of cellular signals
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doi: 10.1097/00005176-199903000-00010

Accordingly, increased E/I ratio has been implicated in autism 7,8

Their interaction with biological systems involved in healing and protection makes them highly relevant for controlled scientific investigations
