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Proc Natl Acad Sci USA 91(16):76887692

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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

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Through mitochondrial transition pore (MTP), calcium enters into mitochondria, enhancing ROS production and misbalancing electron transport chain [243]