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Dobson PD & Kell DB (2008) Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule

IAO, indole aldehyde oxidase

Medin T, Jensen V, Skare O, Storm-Mathisen J, Hvalby O, Bergersen LH

This epigenetic silencing renders tumors initially sensitive to poly ADP ribose polymerase (PARP) inhibitors or platinum-based drugs

A cellular study has clarified that the methyl group brought inside cells by supplementation with MeCbl is not used in any methylation reactions and that supplementation with that form of B 12 does not produce more methionine as compared with supplementation OHCbl.25 The authors stated: Once released from the lysosomes, both MeCbl and OHCbl were converted in the same proportions to coenzyme forms, suggesting equivalent entry into common cellular pools of cobalamin from which active forms are synthesized