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It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+
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Kaji, T
The recommended daily intake (RDI) for individuals over 19 is 2.4 micrograms per day
B12 is a great energy booster and highly recommended mood booster
In research settings, this interaction limits the enzymes normal function
