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The FDA approved thymalfasin, a synthetic version of thymosin alpha-1, as an orphan drug for malignant melanoma and hepatocellular carcinoma, acknowledging its immunomodulatory and anti-tumor effects

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The authors found that the bis(tert-butyl-SATE)-PMEA analog retained similar activity to the bis(POM) compound in cells, but saw a half-life increase of over 50-fold in human serum, suggesting the bis(SATE) prodrug may have better in vivo efficacy [40]

Small heat shock protein responses in leaf tissues of wheat cultivars with different heat susceptibility

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