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doi: 10.1186/bcr1029

Additionally, it demonstrated optimal pharmacokinetic characteristics and bloodbrain barrier permeability in vivo, which are crucial requirements for medications that target the CNS

By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)

Biomol NMR Assign 16 , 267271 (2022)

Lupachik, L.I

We hypothesize that irisin reduces lactate synthesis by inhibiting the HIF-1/LDHA pathway via SIRT1-mediated deacetylation and repairs mitochondrial function through the PGC-1/UCP2 pathway, ultimately improving neuronal damage