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The importance of Cys93 has been demonstrated in animal models

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Beyond primary mitochondrial disorders, in liver mitochondria, MT localizes to the intermembrane space and can be imported into the organelle, where its N-terminal -domain delivers zinc to the electron transport chain, inhibiting respiration in a tissue-specific and zinc-dependent manner

doi: 10.1021/ACSPTSCI.2C00214 74 LiCYaoHWangHFangJYXuJ

By inducing lipid peroxidation and excessive ROS, MTX induces a series of oxidative stress of the intestinal mucosal membrane

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