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Figure 1 2.1 Characterization of Resistance in Cancer Drug resistance in cancer is an intimate occurrence that results when cancer becomes tolerant of pharmaceutical treatment ( Figure 2 )

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Another E3 ligase, SIAH1 is recruited to mitochondria by Synphilin-1 to promote PINK1-dependent mitophagy via mitochondrial ubiquitination in a Parkin-independent manner 74