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Severe diarrhoea, recurring on rechallenge, has been reported in patients treated with azathioprine and pharmacists should be aware that such symptoms might be drug-related[47]

The D-glucose 6-phosphate formed is then converted to GDP-D-mannose via four steps reversible process catalyzed by the enzymes phosphogluco-isomerase, mannose 6-phosphate isomerase, phosphomannose mutase and GDP-D-mannose phosphorylase, respectively

47 Referring to Figure 2, glutathione depletion may be induced by L-dopa administration which can deplete the glutathione sulfur amino acid (thiol) precursor S-adenosyl-methionine, Figure 3

Intervertebral disc L7/S1 was used in the sham group, while L4/5, L5/6 and L6/7 were used in the experimental groups

Science 355 , 2355 (2017)

The study found improvement of SRS in both placebo and oxytocin groups during the double-blind phase, but the difference between the two groups didnt reach statistical significance