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Finally, pre- and post-synaptic GABAergic inhibition is lost and this may produce paradoxical excitation, contributing to neuron hyperexcitability and even to spontaneous neuron activity 146

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Guideline on the format and content of applications for designation as orphan medicinal products and on the transfer of designations from one sponsor to another

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In the unobstructed (control) kidneys, SMA staining was not affected by diet

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