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As mentioned above, there are numerous causes to iron overload

Chronically elevated TNF- levels are linked to autoimmune, cardiovascular, neurodegenerative disease, gum disease, and mood disorders

Excessive autophagy might lead to cell death, which is a new way of cell death in addition to apoptosis and necrosis [128]

Oxidative stress is commonly discussed in the context of illness and physiologic strain in dogs, and antioxidant supplementation has been proposed as supportive care in those situations (Hagen DM, 2019)

Fibrotic tissue can impede axon regeneration

Although preclinical data show promise ( In addressing motor dysfunction induced by METH, transcranial magnetic stimulation has shown potential for restoring motor control by modulating cortical excitability ( Additionally, physical exercise has been recognized as an effective adjunctive intervention for mitigating the cognitive and motor impairments associated with chronic METH use