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10.1016/j.freeradbiomed.2021.02.015 117

Ferroptosis contributes to the progression of diabetes and its complications

Under nutrient-restricted conditions (such as glucose deprivation), cellular energy status shifts, which may activate SIRT2 and other deacetylases by altering the NAD + /NADH ratio or local availability rather than absolute levels

4B) and IL1 (Fig

"Homocysteine"

Glutathione - Synthesis SFRBM Education Program Dickinson et al.13 de novo synthesis - 7 Glycine -glutamylcysteinylglycine -glutamylcysteine (GSH) GSH synthase ATP ADP Glutathione - Synthesis SFRBM Education Program Dickinson et al.14 Glutathione breakdown 1 The linkage of glutamate to cysteine via the gamma carbon makes GSH refractory to standard proteases
